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Protein atlas connects the biologic dots underlying neurodegenerative diseases
FeaturedMedicine 2026-03-23

Protein atlas connects the biologic dots underlying neurodegenerative diseases

(MEMPHIS, Tenn. – March 23, 2026) Neurodegenerative diseases form a tangled biological web with overlapping molecular signatures and symptoms. To decode this complexity, a multi-institute collaboration led by St. Jude Children’s Research Hospital scientists developed the pan-neurodegeneration atlas (PanNDA). The atlas is a comprehensive survey of neurodegenerative disease “proteomes” containing information about protein levels, modifications and interactions. This resource, published today in Cell, provides a wide-ranging protein-based ...
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NASA’s EDGE mission taps Boise State as part of next-generation Earth observation effort
Space 2026-03-23

NASA’s EDGE mission taps Boise State as part of next-generation Earth observation effort

EDGE is one of two next-generation satellite missions announced in February. The mission will help NASA better understand changes to the Earth’s surface and will create detailed 3D maps of vegetation, as well as ice formations like glaciers and sea ice. It builds on the work of two existing NASA satellites, but will do it better and more precisely. This is particularly important for ecosystems in the semi-arid west, where measuring low-height vegetation such as shrubs and vegetation on steep slopes is challenging. Accurate measurement of vegetation ...
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Technology 2026-03-23

AI on deck: assessing impact of MLB’s new ball-strike system

ITHACA, N.Y. - For 150 years, Major League Baseball (MLB) players and fans have accepted that an umpire missing a few balls and strikes is just part of the game. But this spring, MLB is rolling out an artificial intelligence-augmented camera system that will provide a second opinion for players to tap if they think an umpire whiffed. This historic change inspired a Cornell research team to study how MLB stakeholders are integrating the Automated Ball-Strike System (ABS) – which tracks pitches in real time – into baseball’s sacred gameplay. “We hear so much about AI influencing political views and ...
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SwRI hosts grand opening for new 21,000-square-foot Clinical Supply Facility
Medicine 2026-03-23

SwRI hosts grand opening for new 21,000-square-foot Clinical Supply Facility

SAN ANTONIO — March 23, 2026 — Southwest Research Institute (SwRI) celebrated the grand opening of its new Clinical Supply Facility (CSF). The 21,000-square-foot laboratory adds dedicated suites and HEPA filtered cleanrooms to support pharmaceutical development and bioengineering research, particularly in advanced clinical supplies. The facility expands SwRI’s capability to conduct “Fill Finish” for capsules, sachets, tablets and other advanced formulations for all routes of administration. The facility will facilitate the production ...
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Massey researchers lead international collaboration of first-ever, multi-platform digital atlas of oral tissues
Medicine 2026-03-23

Massey researchers lead international collaboration of first-ever, multi-platform digital atlas of oral tissues

RICHMOND, Va. — March 23, 2026 — Researchers at VCU Massey Comprehensive Cancer Center are leading an international study that advances the understanding of the immunoregulatory nature of human tissues, offering breakthrough insights into how fibroblasts serve as the core regulators of structural immunity in the mouth. Serving as the cover story in the first-ever issue of Cell Press Blue, Kevin Matthew Byrd, D.D.S., Ph.D., a member of the Cancer Biology research program at Massey and assistant professor of oral and craniofacial ...
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Medicine 2026-03-23

Improving heart health may not be enough to protect against Alzheimer’s disease

In a recent study, researchers found that exercise and aggressive cardiovascular risk reduction successfully improved heart health, but these efforts did not produce measurable cognitive benefits over two years in older adults at risk for Alzheimer's disease. In “Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults - A Randomized Clinical Trial,” published in JAMA Neurology, researchers, including Dr. Jeffrey Keller of Pennington Biomedical Research Center, shared the results of the Risk Reduction for Alzheimer’s Disease (rrAD) study. They found that interventions ...
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Registrations open for São Paulo School of Advanced Science in Obesity
Medicine 2026-03-23

Registrations open for São Paulo School of Advanced Science in Obesity

The São Paulo School of Advanced Science in Obesity (SPSAS Obesity) will be held on October 19-30, 2026, at the Faculty of Medical Sciences of the State University of Campinas (FCM-UNICAMP) in São Paulo state, Brazil. SPSAS Obesity offers graduate students and early career researchers two weeks of courses, interaction, connection and scientific discussions with leaders in the fields of medical sciences, physiology, biology, genetics, evolution and healthcare. In response to the urgent global rise in obesity — ...
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Science 2026-03-23

Negative emotions at work aren’t always harmful—empathetic leaders make the difference

During a widespread crisis, negative emotions don’t simply go away once the workday begins. Organizational scholars who study how emotions affect employees tend to assume that negative emotions equal negative outcomes. That isn’t always the case, according to new research from David Lebel, associate professor of business administration in the School of Business and director of the Berg Center for Ethics & Leadership.  Working with Pitt doctoral student Jordan Sanders and Jochen Menges at the University of Zurich, Lebel found that during one such crisis–the ...
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Island Scholarship launched
Science 2026-03-23

Island Scholarship launched

A new scholarship scheme launched as part of the Scottish Government’s new National Islands Plan aims to encourage postgraduate students to move to Orkney and study specialist clean energy and marine science.   Heriot-Watt University, the Scottish Government and Orkney Islands Council are behind the programme, which is designed to draw more talent to the islands. While the scheme is being piloted in Orkney, the Scottish Government says its findings will inform wider policy efforts ...
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New findings on the first steps in protein synthesis
Medicine 2026-03-23

New findings on the first steps in protein synthesis

In the earliest phase of creating human proteins, the protein complex NAC performs an essential task by starting the first steps towards folding proteins into their correct three-dimensional structures. This discovery was made by an international research team led by scientists from the Center for Molecular Biology of Heidelberg University. They found that the NAC complex binds to the nascent protein building-blocks formed by the ribosome, i.e., the amino acid chains, and initiates the folding that is essential for functional proteins. According to the scientists, the research ...
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Medicine 2026-03-23

Children with obesity are at risk of disease despite normal test results

Children living with obesity but showing no signs of metabolic complications still have a significantly increased risk of developing type 2 diabetes, high blood pressure, and abnormal blood lipid levels later in life. A new study from Karolinska Institutet, published in JAMA Pediatrics, also shows that these children benefit greatly from obesity treatment. “There has been a debate about whether children with normal blood and liver values and normal blood pressure might not need treatment for their obesity. Our study shows that this assumption is incorrect,” says Claude Marcus, professor at the Department of Clinical Science, Intervention and ...
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New blood marker reduces the risk of a false diagnosis of Alzheimer’s disease
Medicine 2026-03-23

New blood marker reduces the risk of a false diagnosis of Alzheimer’s disease

Brief facts about the study Alzheimer’s disease // clinical, prospective study // longitudinal // cohort study // peer-reviewed // in vivo // The study is published in The Lancet Neurology Alzheimer's disease is characterised by the accumulation of two proteins in the brain: amyloid-beta and tau. Tau normally stabilises the structure of nerve cells, but in this disease the protein undergoes chemical changes and begins to form tangles in the neurons. This altered form is known as p-tau217 and can be measured in the blood. However, the disease develops slowly over ...
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Amid new findings that more migratory species of animals are facing extinction nations gather in Brazil to agree on actions
Environment 2026-03-23

Amid new findings that more migratory species of animals are facing extinction nations gather in Brazil to agree on actions

Campo Grande, Brazil — The 15th Meeting of the Conference of the Parties (COP15) to the Convention on the Conservation of Migratory Species of Wild Animals (CMS) opens here today amid new reports that almost half (49%) of all CMS-listed species have decreasing population trends, and nearly one in four are threatened with extinction.  The State of the World's Migratory Species: Interim Report (2026) paints a stark picture of animals under pressure from a combination of overexploitation, habitat destruction, pollution, climate change, and invasive species.  Over 2,000 participants ...
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Science 2026-03-23

Exploring balance recovery by pulling a rug out from under people

Lena Ting, from Emory University, and colleagues explored how brain and muscle activity during balance recovery change due to aging and Parkinson’s.  Previously, Ting’s research group revealed that when they pulled a rug out from under young adults to trigger balance recovery, these individuals experienced an immediate involuntary brainstem and muscle response followed by a second wave of activity in the brain and muscle in more difficult balance disturbances. In this new study on older adults with and without Parkinson’s, published in eNeuro, the researchers discovered that these populations ...
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Medicine 2026-03-23

Exploring preterm baby brain development

During intensive care after preterm births, babies can experience low oxygen in their tissue and cells—or hypoxia. Hypoxia is linked to poor brain health outcomes and life-long memory issues, but the mechanisms are unclear. Researchers led by Art Riddle and Stephen Back, from Oregon Health and Science University, discovered a contributing mechanism by creating a mouse model for mild hypoxia following premature birth. Riddle emphasizes that, “The field has historically focused on how hypoxia injures white matter in the brain and kills neurons. This is the first study to explore how mild hypoxia ...
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Medicine 2026-03-23

Fathers’ mental health deteriorates long after the birth of their child

Fathers in Sweden are less likely to receive a psychiatric diagnosis during their partner’s pregnancy and in the months following the birth of their child. However, diagnoses of depression and stress-related disorders increase a year later, according to a new study published in JAMA Network Open by researchers at Karolinska Institutet in Sweden and Sichuan University in China. “The transition to fatherhood often involves both positive experiences and a range of new stresses,” says Jing Zhou, PhD student at the Institute of Environmental Medicine, Karolinska Institutet, and co-first author of the paper. “Many ...
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Medicine 2026-03-23

Kids who lose a parent to homicide, suicide or drug overdose are more likely to die as children

Childhood deaths are significantly higher among children who lose a parent to drug overdose, homicide or suicide compared to the general child population, a new University of Michigan study found. The research, published in JAMA Network Open, investigated the link between specific types of parental loss and the subsequent risk of mortality for children in Michigan, said study lead author Sean Esteban McCabe, professor at the U-M School of Nursing.  The study found that bereaved children who experienced a parental death from one of the three preventable causes accounted for 150 excess childhood deaths in the state over the 14-year study period.   "There ...
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Medicine 2026-03-23

Long-term cardiometabolic outcomes in children with metabolically healthy and unhealthy obesity

About The Study: The results this cohort study suggest that children ages 7 to 17 with metabolically healthy obesity at treatment initiation have an increased associated long-term risk of type 2 diabetes, hypertension, and dyslipidemia compared with their peers in the general population. Reduction in BMI z score in pediatric obesity treatment was associated with reduced cardiometabolic risk in children with metabolically healthy and unhealthy obesity to the same extent. Therefore, treatment should also be recommended for children with obesity who appear metabolically healthy.  Corresponding Author: To contact the corresponding ...
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Medicine 2026-03-23

Sleep health dimensions from wearables and transdiagnostic mental health in young adolescents

About The Study: Using Fitbit data in a longitudinal cohort of 3,393 young adolescents, 6 sleep health dimensions were identified: irregularity, timing, duration, social jetlag, weekend oversleep, and continuity. Greater irregularity was associated with higher concurrent transdiagnostic mental health symptoms, whereas shorter duration was associated with higher symptoms at 1-year follow-up. These findings demonstrate the multidimensional nature of adolescent sleep health and can help guide selection of sleep health domains and representative measures to enhance reproducibility and suggest potential intervention ...
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Medicine 2026-03-23

Prescription drug promotion by social media influencers

About The Study: This systematic scoping review study of prescription drug promotion by influencers found that such promotion carried risks of inaccurate or misleading advice, often amplified through personal and emotionally resonant narratives in an environment with limited oversight and enforcement. Despite the small and fragmented evidence base, these findings highlight the urgent need for updated regulatory guidance, standardized and enforceable disclosure requirements, stronger platform accountability, ...
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Science 2026-03-23

Childhood mortality by parental cause of death

About The Study: This statewide cohort study found that childhood mortality is significantly higher among children bereaved by parental drug overdose, homicide, and suicide compared with the general child population. Parental homicide was associated with the highest risk of mortality in children and highlights the need for research into potential explanations, such as the impact on family restructuring and mental health. Corresponding Author: To contact the corresponding author, Sean Esteban McCabe, PhD, email plius@med.umich.edu. To access the embargoed ...
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Science 2026-03-23

Alignment of large language model responses with human therapists in motivational interviewing

About The Study: The findings of this study suggest large language models (LLMs) can produce contextually appropriate motivational interviewing-consistent responses, but limitations in coherence and stylistic alignment highlight the need for further validation before clinical use. Motivational interviewing, a structured counseling approach, provides an empirically grounded setting for evaluating alignment between LLM-generated and human therapist responses. Corresponding Author: To contact the corresponding author, Venkat Bhat, MD, MSc, email venkat.bhat@utoronto.ca. To ...
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Social Science 2026-03-23

Effects of exercise and intensive vascular risk reduction on cognitive function in older adults

About The Study: In this multicenter randomized clinical trial among older adults with family history of dementia and/or self-reported subjective cognitive decline, exercise, intensive pharmacological reduction of cardiovascular risk factors, or both did not result in statistically significant differences in improvements in cognitive function over 24 months. Corresponding Author: To contact the corresponding author, Rong Zhang, PhD, email rongzhang@texashealth.org. To access the embargoed study: Visit our ...
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Science 2026-03-23

Thirty-year trends in multiple sclerosis prevalence, lifestyle factors, and mortality in England

About The Study: In England’s health care system, multiple sclerosis prevalence more than doubled while survival rates increased over 30 years. Substantial gradients in tobacco use, abnormal weight, and socioeconomic deprivation persisted and were associated with mortality. Corresponding Author: To contact the corresponding author, Raffaele Palladino, PhD, MD, email palladino.raffaele@gmail.com. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaneurol.2026.0352) Editor’s Note: Please see the article for additional ...
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Medical centers highlight responsible ways to share genetic disease risk information
Medicine 2026-03-23

Medical centers highlight responsible ways to share genetic disease risk information

 As modern medicine leaps forward in its ability to quickly and more-affordably run genetic disease risk tests, ethical questions have swirled about how best to inform people about risk findings they may have had no idea were coming. What information should stay in de-identified research databases? What should be uploaded into electronic medical records? Who should have access to those records? How much do people want to know about potential bad news in their genetic blueprint? And how should counseling be handled? Over the past six years, a team of Cincinnati Children’s and University of Cincinnati experts led by Leah Kottyan, PhD and Lisa Martin, PhD, has been part of ...
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